EXACT MOA

Mechanism of Action Video

How Does Gene Therapy Work in This Trial?

The gene therapy product XC001 is an altered adenovirus, referred to as the vector, that includes a gene for human vascular endothelial growth factor or VEGF. The vector cannot reproduce and has been shown to be safe in human studies.

  • Once the vector is delivered to the heart and makes its way into cells, it breaks up while delivering the gene into the cell nucleus, where DNA is located.
  • Your own cell machinery makes VEGF protein and then ships it outside the cell where the protein can help new blood vessels form.
  • This is expected to bring more blood and oxygen to areas of the heart that need it.